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KMID : 0882420130850050485
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Korean Journal of Medicine
2013 Volume.85 No. 5 p.485 ~ p.488
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Weight Gain and Improvement of Osteoporosis with Anti-TNF Therapy
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Kim Tae-Hwan
Yun Hyae-Jin
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Abstract
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Ankylosing spondylitis (AS) is a chronic inflammatory disorder primarily involving the sacroiliac joints and spine. It usually affects young people, and bone formation and resorption are implicated in the pathogenesis of AS. Non- steroidal anti-inflammatory drugs (NSAIDs) are the first line therapy and are very effective in most of patients who have inflammatory back pain. If NSAIDs are not effective, anti-TNF-α agents are strongly recommended in severe inflammatory back pain. Anti-TNF-α is very effective in most of AS patients. A study by Lee et al. showed that AS patients who were treated with anti-TNF-α have weight gain and improvement of osteoporosis. In this editorial, studies on the improvement of weight and osteoporosis with anti-TNF-α agents are reviewed.
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KEYWORD
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Anti-TNF, Osteoporosis, Weight gain
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